Tapering Long-term Opioid Therapy in Chronic Noncancer Pain

Tapering Long-term Opioid Therapy in Chronic Noncancer Pain: Evidence and Recommendations for Everyday Practice.

Increasing concern about the risks and limited evidence supporting the therapeutic benefit of long-term opioid therapy for chronic noncancer pain are leading prescribers to consider discontinuing the use of opioids. In addition to overt addiction or diversion, the presence of adverse effects, diminishing analgesia, reduced function and quality of life, or the absence of progress toward function...

Long-term opioid management for chronic noncancer pain.

BACKGROUND Opioid therapy for chronic noncancer pain (CNCP) is controversial due to concerns regarding long-term effectiveness and safety, particularly the risk of tolerance, dependence, or abuse. OBJECTIVES To assess safety, efficacy, and effectiveness of opioids taken long-term for CNCP. SEARCH STRATEGY We searched 10 bibliographic databases up to May 2009. SELECTION CRITERIA We searche...

Long-Term Opioid Therapy for Chronic Pain.

Guideline for opioid therapy and chronic noncancer pain.

CMAJ | MAY 8, 2017 | VOLUME 189 | ISSUE 18 E659 C hronic noncancer pain includes any painful condition that persists for at least three months and is not associated with malignant disease.1 According to seven national surveys conducted between 1994 and 2008, 15%–19% of Canadian adults live with chronic noncancer pain.2 Chronic noncancer pain interferes with activities of daily living, has a maj...

Economic burden of opioid-induced constipation among long-term opioid users with noncancer pain.

BACKGROUND Opioid-induced constipation (OIC) can be a debilitating side effect of opioid therapy and may result in increased medical costs. The published data on the economic burden of OIC among long-term opioid users are limited. OBJECTIVE To assess the economic burden of OIC in patients with noncancer pain in a managed care population in the United States. METHODS This retrospective study...